Kisspeptin Peptide

Kisspeptin-10 is the shortest biologically active fragment of the KISS1 gene product that fully retains potency at the kisspeptin receptor (KISS1R/GPR54). First identified in 2001 as the endogenous ligand associated with pubertal onset, it is now recognized as a key upstream regulator of pulsatile GnRH secretion in experimental models. According to published research, kisspeptin-10 activates GnRH neurons in the hypothalamus through G-protein-coupled receptor signaling, leading to downstream effects on LH and FSH secretion (ncbi.nlm.nih.gov). This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation. For Research Use Only. Not for human use.

Key Scientific Attributes

• High-purity Kisspeptin-10 (≥99% by HPLC/MS, acetate or TFA salt form)
• Verified native decapeptide sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
• Lyophilized formulation for maximum long-term stability
• Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
• Manufactured in GMP-aligned, ISO-compliant facilities
• Studied in the context of GnRH neuron activation and LH/FSH pulsatility research

Research Context (Based on scientific literature; not intended as therapeutic claims.)

• Acts as an upstream regulator of GnRH secretion via KISS1R on hypothalamic GnRH neurons, as documented in neuroendocrine research (pmc.ncbi.nlm.nih.gov)
• Used in experimental models investigating hypothalamic–pituitary–gonadal (HPG) axis signaling
• The most commonly used kisspeptin fragment in biomedical research due to its defined receptor affinity and short sequence
• Studied in reproductive neuroendocrinology, including investigations of GnRH pulse regulation and gonadotropin release

Why Researchers Choose Nationwide Peptides Kisspeptin-10

• Active core sequence consistent with that used in published neuroendocrine research
• Transparent analytical data (HPLC >99%, MS confirmation)
• Trusted by reproductive endocrinology and neuroendocrinology laboratories
• Competitive research pricing with bulk options